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Jul 01, 2020 · Lipase is a beneficial enzyme for your body as it breaks down lipids and regulates their levels in the blood, according to StatPearls Biochemistry, Lipase. Details on Lipase and Weight Loss. Digestive enzyme supplements are known to cause weight loss. Lipase is a compound involved in the break down of fats during digestion. It is found in many plants, animals, bacteria, and molds. Some people use lipase as a medicine.